Adrenocorticotropic hormone secreting monohormonal double pituitary microadenomas causing Cushing's disease

Ectopic Adrenocorticotropic Hormone-Secreting Pituitary Adenomas: An Underestimated Entity.

BACKGROUND The diagnosis of Cushing disease is based on endocrinological pa-rameters, with no single test being specific. In some patients, dynamic thin-slice sellar magnetic resonance imaging fails to detect a pituitary tumor. OBJECTIVE The purpose of this study is to investigate the role of ectopic pituitary adenoma in this situation. METHODS In a retrospective chart review, 5 patients (6...

MR of corticotropin-secreting pituitary microadenomas.

PURPOSE To assess the accuracy of MR in the preoperative identification of corticotropin-secreting pituitary microadenomas. METHODS Twenty-six patients with clinical and biochemical evidence of pituitary-driven Cushing disease in whom MR of the seller region was performed were selected for this study. The MR examinations were retrospectively evaluated by a neuroradiologist who was aware of th...

A FSH-Secreting Pituitary Macroadenoma Causing A Testosterone Deficiency Syndrome

Pituitary Radiotherapy for Cushings Disease

Background: The treatment of choice for Cushing’s disease is pituitary surgery. Second-line treatments include repeat pituitary surgery, radiation therapy, medical therapy, and bilateral adrenalectomy. The most used modalities to irradiate patients with Cushing’s disease include fractionated radiotherapy and single-dose Gamma Knife. We aim to review the efficacy and safety of radiotherapy in pa...

Prolactin-secreting pituitary microadenomas: inaccuracy of high-resolution CT imaging.

Computed tomographic (CT) and surgical findings were correlated retrospectively in 51 patients with preoperative diagnoses of prolactin-secreting pituitary microadenomas. Thirty-nine had microadenomas at surgery. Twenty-three had identifiable discrete lesions. Of these, 21 had microadenomas and two did not; these two groups could not be distinguished reliably. Six patients with proven microaden...